After falling in love with my duvet set, I could not resist buying the crib sheets as a baby present for a friend. I have sensitive skin and use hypoallergenic laundry detergent i.e. baby detergent for all my clothes and bedding. I've had zero irritation using my sheets, and my friend has had the same experience with the crib sheets for her little one. It's a practical, beautiful, and thoughtful gift.